Functional in vitro characterisation of the androgen receptor GGN polymorphism
نویسندگان
چکیده
منابع مشابه
Functional in vitro characterisation of the androgen receptor GGN polymorphism.
Superior androgen receptor (AR) function in subjects carrying a GGN repeat length of 23 (GGN23) has been indicated in vivo. Therefore, the activity of the AR carrying GGN23 combined with CAG22 was compared to the AR with GGN10, 24 and 27, respectively, in the presence of 0.1-100 nM testosterone or DHT. At 100 nM DHT, GGN24 showed 35% lower transactivating activity (95% [CI]: 20-50%) than GGN23....
متن کاملassociation of androgen receptor ggn repeat length polymorphism and male infertility in khuzestan, iran
background: androgens play critical role in secondary sexual and male gonads differentiations such as spermatogenesis, via androgen receptor. the human androgen receptor (ar) encoding gene contains two regions with three nucleotide polymorphic repeats (cag and ggn) in the first exon. unlike the cag repeats, the ggn has been less studied because of technical difficulties, so the functional role ...
متن کاملAssociation of androgen receptor GGN repeat length polymorphism and male infertility in Khuzestan, Iran
BACKGROUND Androgens play critical role in secondary sexual and male gonads differentiations such as spermatogenesis, via androgen receptor. The human androgen receptor (AR) encoding gene contains two regions with three nucleotide polymorphic repeats (CAG and GGN) in the first exon. Unlike the CAG repeats, the GGN has been less studied because of technical difficulties, so the functional role o...
متن کاملAssociations between androgen receptor CAG & GGN repeat polymorphism & recurrent spontaneous abortions in Chinese women
BACKGROUND & OBJECTIVES Recurrent spontaneous abortion (RSA) is a reproductive problem that occurs in women in reproductive age with a frequency of 1-3 per cent. Previous studies have reported high levels of serum androgens to be associated with RSAs. At the molecular level, the effect of androgens is mediated through the activation of the androgen receptor (AR). The CAG and GGN repeat polymorp...
متن کاملThe androgen receptor gene GGN microsatellite and prostate cancer risk.
The androgen receptor (AR) gene contains a polymorphic GGN microsatellite in exon 1, which encodes polyglycine in the amino terminus of the AR. Previous work has shown that a polymorphic region of CAG repeats also in exon 1 is inversely related to the ability of the AR to transactivate other genes and to prostate cancer risk. We investigated whether AR gene GGN repeat length is related to prost...
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ژورنال
عنوان ژورنال: Molecular and Cellular Endocrinology
سال: 2007
ISSN: 0303-7207
DOI: 10.1016/j.mce.2006.11.008